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QRAR models for central nervous system drugs using biopartitioning micellar chromatography
C Quiñones-Torrelo1, Y Martin-Biosca, J J Martínez-Pla
1Departamento de Química Analítica. Facultad de Farmacia. Universitat de Valencia, C/Vicente Andrés Estellés s/n, Valencia, E-46100 Burjassot, Spain.
Abstract:
The capability of biopartitioning Micellar Chromatography, BMC, to describe and estimate pharmacokinetic and pharmacodynamic parameters of central nervous system drugs is reviewed in this article. BMC is a mode of micellar liquid chromatography, MLC, that uses micellar mobile phases of Brij35 (polyoxyethilene(23) lauryl ether) prepared in physiological conditions (pH, ionic strength). The retention of a drug in this system depends on its hydrophobic, electronic and steric properties, which also determine its biological activity. The results of BMC studies suggest that this in vitro approach is an attractive useful tool to be implemented into the lead optimization step of drug development scheme.