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Aggressive digital papillary adenocarcinoma arising on the right great toe
Osamu Mori1, Takekuni Nakama, Takashi Hashimoto
1Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Japan. moriosa@med.kurume-u.ac.jp
European Journal of Dermatology : EJD
|October 9, 2002
Summary
A rare case of aggressive digital papillary adenocarcinoma was identified in a young man. This foot tumor exhibited unique histological and immunohistochemical features, distinguishing it from other skin cancers.
Area of Science:
- Oncology
- Dermatopathology
- Surgical Pathology
Background:
- Digital papillary adenocarcinoma is a rare malignant neoplasm arising from sweat glands.
- Aggressive variants present diagnostic challenges due to their histology and location.
Observation:
- A 20-year-old Japanese male presented with an aggressive digital papillary adenocarcinoma on his right great toe.
- Histological examination revealed multiple lobules of epithelial cells with solid areas and fused back-to-back glands.
- Tumor cells showed positive immunohistochemical staining for S-100 protein, but were negative for EMA, CEA, and GCDFP.
Findings:
- The tumor demonstrated continuity with the epidermis, lacking cystic spaces and apocrine-like secretion.
- Intraluminal contents tested positive for CEA and EMA, contrasting with the neoplastic cells.
- The distinct histological and immunohistochemical profile supported the diagnosis of aggressive digital papillary adenocarcinoma.
Implications:
- Accurate diagnosis is crucial for appropriate treatment and management of aggressive digital papillary adenocarcinoma.
- Understanding the immunohistochemical profile aids in differentiating this tumor from other adnexal neoplasms.
- This case highlights the importance of thorough histopathological evaluation in rare digital tumors.