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[Micronuclei induced by chronic inhalation of SO2 in mouse bone marrow cells]
Ziqiang Meng1, Aidong Ruan, Nan Sang
1Institute of Environmental and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan 030006.
Huan Jing Ke Xue= Huanjing Kexue
|October 10, 2002
Abstract:
In the chronic inhalation experiment of sulfur dioxide(SO2), micronuclei(MN) frequencies in the polychromatophilic erythroblasts(PCE) of mouse bone marrow and the frequencies of cells with MN were significantly increased in dose-dependent manner. There was a significant difference between the male and the female animals. The results also showed that SO2 inhibited urethone-induced MN formation. These results furtherly confirm that SO2 inhalation was a clastogenic and genotoxic agent to mammalian cells, and the combined effects of SO2 and other mutagens are complex.