Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Diversity and sensorimotor specialization of head direction cells in the mouse thalamus.

Current biology : CB·2026

Same author

Coherent Subgap Transport in Spin-Split Josephson Junctions.

Physical review letters·2026

Same author

The neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions.

Nature neuroscience·2026

Same author

Scientific Histories of Hippocampal Research: Introduction to the Special Issue Part 2.

Hippocampus·2026

Same author

A feature-based generalizable prediction model for both perceptual and abstract reasoning.

Cognitive neuroscience·2025

Same author

Relative phase of membrane potential theta oscillations between individual hippocampal neurons code space.

bioRxiv : the preprint server for biology·2025

Same journal

Q-learning based asynchronous Boolean control networks stabilization with data loss.

Neural networks : the official journal of the International Neural Network Society·2026

Same journal

New results on prescribed-time synchronization of complex networks via intermittent control.

Neural networks : the official journal of the International Neural Network Society·2026

Same journal

Variance-constrained multi-view ensemble broad network for imbalanced data.

Neural networks : the official journal of the International Neural Network Society·2026

Same journal

Dynamic analysis and reliable mechanical optimization application of ring HNN effected with a memristive neuron.

Neural networks : the official journal of the International Neural Network Society·2026

Same journal

DAFF-Net: A detection and search method for small-scale low surface brightness galaxies.

Neural networks : the official journal of the International Neural Network Society·2026

Same journal

Quasi-synchronization for complex networks with hybrid pinning intermittent control.

Neural networks : the official journal of the International Neural Network Society·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 3, 2026

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

Neuromodulation, theta rhythm and rat spatial navigation.

Michael E Hasselmo¹, Jonathan Hay, Maxim Ilyn

¹Department of Psychology, Center for BioDynamics, Boston University, MA 02215, USA. hasselmo@bu.edu

Neural Networks : the Official Journal of the International Neural Network Society

|October 10, 2002

Summary

This summary is machine-generated.

Cholinergic and GABAergic systems in the hippocampus are crucial for memory and spatial navigation. Understanding their interaction, particularly during theta rhythm, can enhance navigation strategies.

More Related Videos

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

Related Experiment Videos

Last Updated: May 3, 2026

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

Area of Science:

Neuroscience
Cognitive Science

Background:

Cholinergic and GABAergic systems in the hippocampus are vital for memory and spatial navigation.
Impairments in these systems affect the encoding of new information and spatial tasks.

Purpose of the Study:

To review the role of cholinergic modulation in memory.
To present a new model of hippocampus and entorhinal cortex interaction for spatial navigation.
To explore how hippocampal theta rhythm phases support distinct navigation functions.

Main Methods:

Review of existing literature on cholinergic modulation and memory.
Development of a computational model of hippocampus-entorhinal cortex interaction.
Analysis of physiological variables during hippocampal theta rhythm.

Main Results:

Cholinergic system lesions impair spatial navigation tasks.
A model is proposed where distinct functional phases are required for encoding and retrieval.
Phasic changes in theta rhythm may facilitate these separate phases.

Conclusions:

The hippocampus and entorhinal cortex interact for goal-directed spatial navigation.
Separate encoding and retrieval phases are necessary for effective navigation.
Hippocampal theta rhythm dynamics are key to supporting these distinct functional phases.