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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Related Experiment Video

Updated: Jul 9, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

Rothman and Schekman SNAREd by Lasker for trafficking.

Vivek Malhotra1, Scott D Emr

  • 1Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093, USA. malhotra@biomail.ucsd.edu

Cell
|October 10, 2002
PubMed
Summary
This summary is machine-generated.

James Rothman and Randy Schekman received the Lasker Award for their groundbreaking research on membrane traffic mechanisms. Their work significantly advanced our understanding of how cells transport essential molecules.

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Shotgun Lipidomics of Rodent Tissues
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Shotgun Lipidomics of Rodent Tissues

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Last Updated: Jul 9, 2026

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Shotgun Lipidomics of Rodent Tissues
11:46

Shotgun Lipidomics of Rodent Tissues

Published on: November 18, 2022

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cellular processes rely on the precise transport of molecules within membrane-bound compartments.
  • Dysfunctional membrane traffic is implicated in numerous diseases, including neurological disorders and metabolic conditions.

Purpose of the Study:

  • To recognize the seminal contributions of James Rothman and Randy Schekman to understanding membrane traffic.
  • To elucidate the molecular machinery governing vesicle transport and fusion.

Main Methods:

  • The research involved genetic analysis in yeast and biochemical reconstitution of vesicle transport in mammalian cells.
  • Key proteins and pathways regulating vesicle budding, targeting, and fusion were identified.

Main Results:

  • Rothman and Schekman identified the molecular players and regulatory principles of vesicle-mediated transport.
  • Their work revealed how vesicles dock and fuse with target membranes, ensuring accurate delivery of cellular cargo.

Conclusions:

  • The discoveries by Rothman and Schekman provide a fundamental framework for cellular logistics.
  • This research has profound implications for understanding health and disease, opening avenues for therapeutic interventions.