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Novel lopinavir analogues incorporating non-Aromatic P-1 side chains--synthesis and structure--activity relationships
Hing L Sham1, Chen Zhao, Leping Li
1Pharmaceutical Discovery, R47B, Building AP-10, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. hing.l.sham@abbott.com
Bioorganic & Medicinal Chemistry Letters
|October 10, 2002
Abstract:
The HIV protease inhibitor Lopinavir has a pseudosymmetric core unit incorporating benzyl groups at both P-1, P-1' positions. A series of analogues incorporating non-aromatic side chains at the P-1 position were synthesized and the structure-activity relationships explored.