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Renal amyloidosis secondary to tuberculosis of cecum
A S El-Hennawy1, M Goldstein, A Nicastri
1Department of Medicine, Renal Division, Coney Island Hospital, Brooklyn, N.Y. 11235, USA. goodkidney@aol.com
Abstract:
Renal amyloidosis can occur as a primary or secondary, systemic or localized disorder. It is defined as a chronic infiltrative disorder characterized by impaired organ function caused by extracellular insoluble protein fibrils. Although colonic tuberculosis is not uncommon, the occurrence of reactive renal amyloidosis in such patients is not as prevalent. We report a single case of renal amyloidosis in a patient with tuberculosis of the cecum who presented with nephrotic syndrome.
Insights
This case report highlights a rare instance of reactive renal amyloidosis in a patient with cecal tuberculosis. The study emphasizes the importance of considering this unusual complication in patients presenting with nephrotic syndrome.
Area of Science:
- Nephrology
- Pathology
- Infectious Diseases
Background:
- Renal amyloidosis is a systemic disorder involving extracellular protein fibril deposition, leading to impaired kidney function.
- While colonic tuberculosis is relatively common, its association with reactive renal amyloidosis is infrequent.
- Amyloidosis presents as a primary or secondary, systemic or localized condition.
Observation:
- A single case of renal amyloidosis was identified in a patient diagnosed with tuberculosis of the cecum.
- The patient presented with nephrotic syndrome, a clinical manifestation of kidney damage.
Findings:
- The case demonstrates a rare occurrence of reactive renal amyloidosis secondary to colonic tuberculosis.
- Nephrotic syndrome was the presenting clinical feature, indicating significant renal impairment.
Implications:
- This report underscores the need for heightened clinical suspicion for renal amyloidosis in patients with tuberculosis, particularly those with gastrointestinal involvement.
- Early diagnosis and management of reactive renal amyloidosis can potentially mitigate severe kidney damage.
- Further research may elucidate the precise mechanisms linking tuberculosis and amyloidosis, aiding in preventative strategies.