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Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the
J M Wieronska1, B Szewczyk, P Branski
1Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
Amino Acids
|October 10, 2002
Abstract:
Using the olfactory bulbectomy model of depression, we examined the antidepressant-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Bulbectomized rats required a significantly greater number of trials to acquire the response similar to sham-operated controls in the passive avoidance model. Both the prolonged (but not acute) treatment with MPEP and with antidepressant drug-desipramine restored the learning deficit. The results indicate that the prolonged blockade of mGlu5 receptors exerts antidepressant-like effects in rats.