Electron microscopy study of the development of neurovaccinia virus in rabbit blood leucocyte cultures

In electron microscopy of rabbit blood leucocytes cultured after infection with a large dose of neurovaccinia virus, virus particles can be observed within 24 hours in the cytoplasm of the monocytoid cells (monocytes and macrophages) and occasionally in the polymorphonuclear cells, but never in the lymphocytes. The morphology of the virus particles does not differ from the description of these particles in other types of host cells. The virus replication cycle in the monocytoid cells is slow and the virus matures asynchronously. Virus replication causes infected cells to disintegrate.