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Development of co- and post-translational synthetic strategies to C-neoglycopeptides
Glenn J McGarvey1, Tyler E Benedum, Frank W Schmidtmann
1Department of Chemistry, University of Virginia, Charlottesville, Virginia 22901, USA. gjm@virginia.edu
Organic Letters
|October 12, 2002
Abstract:
[reaction: see text] The synthesis of stable, C-linked analogues of glycopeptides is being investigated with two complementary synthetic strategies, co-translational and post-translational glycopeptide synthesis. The key feature of the present approach lies in an effective olefin cross-metathesis reaction that allows formation of both glycoamino acids and glycopeptides.