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[Association between aldosterone synthase gene polymorphism and hypertrophic cardiomyopathy]
Ai-Hua Chen1, Wen-Xiu Zhang, Zhi-Liang Li
1Department of Cardiology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. chenaha@21.cn.com
Objective:
To investigate the relationship between aldosterone synthase (CYP11B2) gene polymorphism and hypertrophic cardiomyopathy (HCM).
Methods:
Fifteen HCM patients and 18 healthy subjects were enrolled in this study. Peripheral blood samples were collected from these subjects to exact genome DNA. PCR and Hae III restriction endonuclease digestion were employed to study -344C/T polymorphism of CYP11B2 gene.
Results:
CYP11B2 gene showed a significant difference in CT genotype distribution in HCM groups as compared with that in the control groups (P<0.05).
Conclusion:
CT genotype of CYP11B2 gene may be one of factors responsible for the pathogenesis of HCM in a proportion of patients.