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Left ventricular systolic dysfunction in patients with obstructive sleep apnea syndrome
Jean-Pierre Laaban1, Sophie Pascal-Sebaoun, Evelyne Bloch
1Department of Pneumology, Hotel-Dieu Hospital, 1 place du Parvis Notre-Dame, 75181 Paris Cedex 04, France. j-pierre.laaban@htd.ap-hop-paris.fr
Chest
|October 16, 2002
Summary
Obstructive sleep apnea syndrome (OSAS) can cause daytime left ventricular (LV) systolic dysfunction. This condition may resolve after treatment for sleep apnea, highlighting a direct link.
Area of Science:
- Cardiology
- Pulmonology
- Sleep Medicine
Background:
- Conflicting data exists on obstructive sleep apnea syndrome (OSAS) effects on left ventricular (LV) systolic function.
- Assessing LV systolic function in OSAS patients is crucial for understanding cardiovascular implications.
Purpose of the Study:
- To determine the prevalence and causes of LV systolic dysfunction in a large cohort of OSAS patients.
- To investigate the role of OSAS as a direct cause of impaired LV systolic function.
Main Methods:
- Prospective study involving 169 OSAS patients diagnosed via polysomnography.
- Radionuclide ventriculography used to measure LV ejection fraction (LVEF); further cardiac investigations for dysfunction.
- Exclusion of patients with pre-existing cardiac disease.
Main Results:
- LV systolic dysfunction (LVEF < 50%) found in 7.7% of OSAS patients.
- No silent cardiac disease identified as a cause in affected patients.
- LV function normalized in seven patients after OSAS treatment.
Conclusions:
- OSAS may directly cause reversible daytime LV systolic dysfunction.
- Treatment of nocturnal apneas can restore normal LV systolic function.
- Highlights the importance of managing OSAS for cardiac health.