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[New total synthesis of derrusnine]
S Kirkiacharian1, H Chidiack, S Maïga
1Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de Paris-Sud 5, rue Jean-Baptiste Clément, F92296 Chatenay-Malabry Cedex, France.
Annales Pharmaceutiques Francaises
|October 16, 2002
Abstract:
The thermal condensation of diethyl 3,4-methylenedioxyphenylmalonate with 3,5-dimethoxyphenol (di-O-methylphloroglucinol) leads to the corresponding 3-(3,4-méthylenedioxyphenyl)-4-hydroxy-5,7-dimethoxycoumarine which is methylated further into derrusnine.