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Updated: Jul 29, 2026

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Mutation analysis of APC gene in gastric cancer with microsatellite instability

Dian-Chun Fang1, Yuan-Hui Luo, Shi-Ming Yang

  • 1Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. fangdianchun@hotmail.com

World Journal of Gastroenterology
|October 16, 2002
PubMed
Abstract

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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