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Updated: Aug 14, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
Published on: May 3, 2018
[Arterial pulse pressure]
1Service de médecine interne et HTA, Hôpital Saint-Michel, 33, rue Olivier de Serres 75730 Paris. jean-jacques.mourad@hopital-saint-michel.org
Insights
Arterial pulse pressure is an independent cardiovascular risk factor, even in patients with controlled blood pressure. Measuring pulse pressure is a simple, effective tool for identifying individuals at high risk for heart disease.
Area of Science:
- Cardiology
- Hypertension Research
- Vascular Medicine
Context:
- Arterial pulse pressure (PP) is an independent predictor of cardiovascular and coronary risk.
- Its significance is established in untreated hypertension, controlled hypertension, normal blood pressure, and high-risk populations (heart failure, post-infarction, hemodialysis).
Purpose:
- To highlight the independent role of pulse pressure in cardiovascular risk assessment.
- To discuss the therapeutic implications and current limitations regarding pulse pressure management.
- To emphasize pulse pressure as a valuable screening marker.
Summary:
- Pulse pressure, distinct from systolic, diastolic, and mean pressure, is a quantified independent risk factor for cardiovascular and coronary events.
- This risk is evident across various patient groups, including those with controlled or normal blood pressure and high-risk populations.
- Antihypertensive treatments show variable efficacy on pulse pressure, with new therapies emerging, but prognostic improvement via PP reduction is not yet proven.
Impact:
- Pulse pressure measurement offers a simple and pertinent tool for clinicians to screen individuals at elevated cardiovascular and coronary risk.
- Further research is needed to establish therapeutic strategies targeting pulse pressure reduction for improved cardiovascular outcomes.
- Highlights the need for incorporating pulse pressure assessment into routine clinical practice for risk stratification.
Abstract:
A WELL IDENTIFIED RISK FACTOR: Other than systolic, diastolic and mean pressure, arterial pulse pressure (or differential pressure) is an independent factor of cardiovascular and notably coronary risk. The role of this factor is now clearly quantified in untreated hypertensive patients, but also in treated apparently controlled patients, and in patients with normal blood pressure. Demonstration of the deleterious role of an increase in pulse pressure was also made in populations at high risk of events such as heart failure, post-infarction or in hemodialyzed patients. FROM A THERAPEUTIC POINT OF VIEW: Antihypertensive treatments have inconstant efficacy on pulse pressure and new therapeutic routes appear promising. However, in the absence of available proof that a strategy axed on the decrease in pulse pressure improves cardiovascular prognosis, current recommendations do not yet include pulse pressure levels in therapeutic strategies. AN EFFICIENT MARKER: Whilst awaiting further data, the measurement of pulse pressure, because of its pertinence and simplicity, provides the practitioner with one of the most efficient markers for screening persons at high risk of cardiovascular and particularly coronary risk.
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