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Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
Published on: November 17, 2017
Practical guidelines for the clinical use of plasma
Peter Hellstern1, Wolfgang Muntean, Wolfgang Schramm
1Institute of Hemostaseology and Transfusion Medicine, City Hospital Ludwigshafen, Bremserstrasse 79, D-67063, Ludwigshafen, Germany. peterhellstern@medicusnet.de
Thrombosis Research
|October 16, 2002
Summary
Fresh frozen plasma (FFP) and solvent/detergent-treated plasma show similar clinical efficacy. Plasma administration for coagulopathy requires clinical and laboratory verification, except in emergencies, with rapid infusion crucial for efficacy.
Area of Science:
- Hematology
- Transfusion Medicine
Background:
- Clinical efficacy of fresh frozen plasma (FFP) and solvent/detergent-treated plasma is comparable.
- Evidence supporting plasma efficacy relies heavily on observational studies and expert opinion.
Purpose of the Study:
- To review the indications and administration guidelines for plasma transfusion.
- To compare the efficacy and safety of different plasma products.
Main Methods:
- Review of prospective controlled clinical trials, observational studies, and expert consensus.
- Analysis of evidence for plasma use in various coagulopathic conditions.
Main Results:
- No significant difference in clinical efficacy or tolerance between FFP and solvent/detergent-treated plasma.
- Plasma administration for coagulopathy necessitates clinical and laboratory confirmation, except in emergencies.
- Rapid infusion (≥10 ml/kg) is essential for significant protein level increase.
Conclusions:
- Plasma is indicated for complex coagulopathy in massive transfusion, DIC, and liver disease.
- Therapeutic plasma exchange is the primary treatment for TTP-HUS.
- Prothrombin complex concentrates are preferred over plasma for reversing oral anticoagulation.
