CD5+ T-cell/histiocyte-rich large B-cell lymphoma
Chung-Che Chang1, Ellen Bunyi-Teopengco, Camellia Eshoa
1Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. jeffchang@pol.net
Summary
This study reports the first documented case of CD5-positive T-cell/histiocyte-rich large B-cell lymphoma. The CD5 expression on neoplastic B-cells was confirmed, suggesting a potential new variant requiring further investigation.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare subtype of diffuse large B-cell lymphoma.
- The expression of CD5 in neoplastic B-cells within THRLBCL has not been previously reported.
Observation:
- The first documented case of CD5-positive THRLBCL is presented.
- Histomorphology, immunohistochemistry, flow cytometry, and molecular studies confirmed the presence of CD5 on neoplastic large B-cells.
- Immunophenotyping revealed CD5, CD19, and kappa expression on clonal B-cells.
Findings:
- Neoplastic large B-cells expressed bcl-6 and MUM1/IRF4, suggesting a late germinal-center or early post-germinal-center B-cell origin.
- The patient achieved complete remission following chemotherapy with Cytoxan, doxorubicin, vincristine, and prednisone (CHOP) plus Rituxan.
- The CD5+ THRLBCL is proposed as a variant of de novo CD5+ diffuse large B-cell lymphomas.
Implications:
- This finding may represent a distinct variant of THRLBCL.
- Further studies are needed to elucidate the clinical and biological significance of CD5 expression in THRLBCL.
- Awareness of this CD5+ variant may prompt routine CD5 staining in THRLBCL cases, aiding in diagnosis and understanding disease characteristics.
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