Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Protective role of the Doderleïn flora].

J P Lepargneur1, V Rousseau

  • 1Laboratoire des Carmes, CEDIBIO, 9, avenue Etienne-Billières, 31000 Toulouse, France.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|October 16, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

North Atlantic Heat Transport Convergence Derived from a Regional Energy Budget Using Different Ocean Heat Content Estimates.

Surveys in geophysics·2024
Same author

Growth velocity of fetal sacrococcygeal teratoma as predictor of perinatal morbidity and mortality: multicenter study.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2024
Same author

[Validation of identification criteria for patients having surgery for rhegmatogenous retinal detachment at Toulouse University Hospital].

Journal francais d'ophtalmologie·2023
Same author

[Early diagnosis of omphalocele: Prognostic value of the herniated viscera for associated anomalies].

Gynecologie, obstetrique, fertilite & senologie·2019
Same author

Acute ischaemic lesions are associated with cortical superficial siderosis in spontaneous intracerebral hemorrhage.

European journal of neurology·2018
Same author

Management and outcome of neonates with a prenatal diagnosis of esophageal atresia type A: A population-based study.

Prenatal diagnosis·2018
Same journal

[Neuroprotection for preterm infants with antenatal magnesium sulphate].

Journal de gynecologie, obstetrique et biologie de la reproduction·2017
Same journal

[Is universal screening for cervical length among singleton pregnancies with no history of preterm birth justified?]

Journal de gynecologie, obstetrique et biologie de la reproduction·2017
Same journal

[Lifestyle recommendations for prevention of spontaneous preterm birth in asymptomatic pregnant women].

Journal de gynecologie, obstetrique et biologie de la reproduction·2017
Same journal

[Guidelines for clinical practice: Prevention of spontaneous preterm birth (excluding preterm premature rupture of membranes) - Introduction].

Journal de gynecologie, obstetrique et biologie de la reproduction·2017
Same journal

[Psychological aspects of abortion].

Journal de gynecologie, obstetrique et biologie de la reproduction·2016
Same journal

[Induced abortion: Guidelines for clinical practice - Introduction].

Journal de gynecologie, obstetrique et biologie de la reproduction·2016
See all related articles

Healthy vaginal flora relies on Doderleïn bacilli (lactobacilli) to inhibit harmful microbes. Probiotics offer a new therapeutic strategy to restore this crucial vaginal microbiome balance.

Area of Science:

  • Microbiology
  • Gynecology
  • Immunology

Context:

  • The vaginal microbiome is dominated by Doderleïn bacilli (lactobacilli), crucial for maintaining a healthy vaginal environment.
  • These beneficial bacteria form a protective biofilm on the vaginal mucosa, inhibiting the growth and adhesion of pathogenic microorganisms.

Purpose:

  • To elucidate the mechanisms by which lactobacilli maintain vaginal homeostasis.
  • To explore the disruption of vaginal flora by external factors like antibiotics and spermicides.
  • To introduce probiotics as a therapeutic strategy for restoring a balanced vaginal microbiome.

Summary:

  • Lactobacilli exert beneficial effects through various mechanisms, including organic acid secretion, antimicrobial substance production (hydrogen peroxide, bacteriocins, biosurfactants), nutrient and receptor competition, steric exclusion, and co-aggregation.

Related Experiment Videos

  • Disruption of this delicate ecological balance can occur due to medications (antibiotics, spermicides) or local devices.
  • Probiotic therapy, utilizing combinations of lactobacilli with synergistic antimicrobial activities, is proposed as a novel approach to restore normal vaginal flora.

    • Impact:

    • Understanding these mechanisms enhances knowledge of the vaginal microbiome's role in women's health.
    • Identifying factors that disrupt vaginal flora can inform preventative strategies.
    • Probiotic interventions show promise for treating and preventing conditions associated with vaginal dysbiosis.