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Related Experiment Videos

Excipient-drug interactions in parenteral formulations.

Michael J Akers1

  • 1Baxter Healthcare Corporation, Bloomington, Indiana 47402, USA. michael_akers@baxter.com

Journal of Pharmaceutical Sciences
|October 16, 2002
PubMed
Summary

Excipients in parenteral formulations can improve drug solubility and stability, but may also cause negative interactions. Understanding these drug-excipient interactions is crucial for parenteral product development.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Formulation Development

Background:

  • Excipients are essential components in parenteral formulations, serving various functions.
  • These functions include enhancing solubility, maintaining stability, ensuring safety, and controlling drug release.
  • Positive interactions between excipients and drugs are common, but negative interactions can also occur.

Purpose of the Study:

  • To review documented synergistic and antagonistic interactions between excipients and drugs in parenteral formulations.
  • To enhance understanding of the implications of excipient addition to parenteral drug products.

Main Methods:

  • Literature review of documented drug-excipient interactions in parenteral formulations.
  • Analysis of both positive (synergistic) and negative (antagonistic) effects.

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Main Results:

  • Excipients can positively impact drug solubility, stability, safety, and delivery.
  • Conversely, excipients can lead to detrimental effects like reduced drug solubility, activity, and stability.
  • Documented examples of both beneficial and detrimental interactions are highlighted.

Conclusions:

  • Drug-excipient interactions significantly influence the performance and safety of parenteral formulations.
  • A thorough understanding of these interactions is critical for successful parenteral drug product development.
  • Careful selection and evaluation of excipients are necessary to optimize parenteral formulations.