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Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
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Basics of Sterile Compounding: Excipients Used in Injections.

Michael J Akers1

  • 1Baxter BioPharma Solutions, Bloomington, Indiana. mjakers356@gmail.com.

International Journal of Pharmaceutical Compounding
|July 19, 2017
PubMed
Summary

This study examines various excipients, which are all components of pharmaceutical formulations. Understanding these ingredients is crucial for developing effective drug delivery systems.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Formulation
  • Materials Science

Background:

  • Excipients are integral components of pharmaceutical formulations, influencing drug stability, bioavailability, and delivery.
  • A comprehensive understanding of diverse excipient functionalities is essential for successful drug product development.

Purpose of the Study:

  • To provide an overview of the various types of excipients used in pharmaceutical formulations.
  • To highlight the critical role of excipients in determining the performance of drug products.

Main Methods:

  • Literature review of common pharmaceutical excipients.
  • Categorization of excipients based on their function (e.g., binders, fillers, disintegrants, coatings).

Main Results:

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  • Detailed discussion on the properties and applications of various excipient classes.
  • Examples of how specific excipients impact drug release profiles and stability.

Conclusions:

  • Excipients are critical determinants of drug product quality and efficacy.
  • Selection of appropriate excipients is paramount for achieving desired therapeutic outcomes.