Radiation therapy of malignant melanoma

This article discusses that previously considered radioresistant, malignant melanomas clearly have been shown to respond either to conventional or high-dose-per-fraction radiation therapy. Approximately one fourth of palliatively irradiated malignant melanomas respond completely and another one third respond substantially. Some physicians have controlled small-volume macroscopic tumors by radiation therapy, but such treatment has not gained wide acceptance. Elective irradiation of anatomic sites considered likely to harbor microscopic-size tumor unquestionably decreases the risk of local-regional recurrence. The inability of available systemic therapies, however, to prevent the appearance of distant metastases limits the current impact of such treatment.