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Related Experiment Videos

Herpes simplex virus colitis in a neonate.

Andrew J Daley1, Paul Craven, Andrew J A Holland

  • 1Departments of Immunology and Infectious Diseases, Royal Alexandra Hospital for Children, Westmead, Australia.

The Pediatric Infectious Disease Journal
|October 17, 2002
PubMed
Summary

Congenital herpes simplex virus (HSV) infection in newborns can affect the gastrointestinal tract, leading to severe bleeding and colon perforation. Early detection and understanding of gastrointestinal involvement are crucial for managing neonatal HSV.

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Area of Science:

  • Neonatal infections
  • Gastroenterology
  • Virology

Background:

  • Congenital herpes simplex virus (HSV) infection is a serious condition in newborns.
  • Gastrointestinal (GI) tract involvement in neonatal HSV is infrequently documented.
  • Understanding the spectrum of HSV manifestations is critical for timely diagnosis and treatment.

Observation:

  • A case of a newborn with disseminated HSV infection presenting with significant hematochezia is described.
  • The infant developed a late-onset sigmoid colon perforation.
  • Histological analysis revealed ulcerations and multinucleated giant cells in the colon.

Findings:

  • Polymerase chain reaction (PCR) confirmed the presence of HSV nucleic acid in the colonic tissue.
  • The clinical presentation included severe gastrointestinal bleeding and perforation.

Related Experiment Videos

  • No recurrent colitis episodes were observed during the first year of life.

    • Implications:

    • This case highlights the potential for severe GI complications in neonatal HSV.
    • It underscores the importance of considering HSV in neonates with unexplained hematochezia and abdominal emergencies.
    • Further research into the pathogenesis and management of GI involvement in neonatal HSV is warranted.