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Updated: Sep 28, 2026
A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery
Published on: September 9, 2022
Transient mechanical benefits of a deep inflation in the injured mouse lung
Gilman Allen1, Lennart K A Lundblad, Polly Parsons
1Department of Medicine, Vermont Lung Center, University of Vermont, Burlington, Vermont 05405, USA. gballen@zoo.uvm.edu
Abstract:
The lasting effects of a recruitment maneuver (RM) in the injured lung are not well characterized. We speculated that the reduction in respiratory elastance (H) after a deep inflation (DI) is transient in nature and should be sustained longer at higher positive end-expiratory pressure (PEEP). Thirteen ventilated mice were given 2 DIs at various levels of PEEP before and after saline lavage. Forced oscillations were used to measure H periodically over 7 min after the DIs. Time constants (tau) were estimated for the post-DI recovery in H. Values for tau before lavage (80-115 s) were reduced after lavage (13-30 s) at all levels of PEEP (P = 0.0001). PEEP did not significantly influence tau before or after lavage. The plateau level and total recovery in H after a DI were significantly influenced by PEEP and lavage (P < 0.0001). Our results suggest that for a DI to be beneficial in the injured mouse lung, it may have to be applied several times a minute.
