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Fondaparinux sodium does not cross the placental barrier: study using the in-vitro human dually perfused cotyledon

Fabrice Lagrange1, Jean-Luc Brun, Marie Christine Vergnes

  • 1Department of Pharmacology, Victor Segalen Bordeaux University, Bordeaux, France.

Clinical Pharmacokinetics
|October 18, 2002
PubMed
Abstract

No abstract available in PubMed .

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Physiological Barriers01:25

Physiological Barriers

Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...

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