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Porphyria cutanea tarda presenting as cicatricial conjunctivitis
Anna J Park1, Guy F Webster, Robert B Penne
1Cornea Service, Wills Eye Hospital, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA. parkajangyun@yahoo.com
Purpose:
To report a case of porphyria cutanea tarda presenting as cicatricial conjunctivitis.
Design:
Observational study.
Methods:
A 31-year-old man presented with bilateral inferior symblepharon, superior tarsal conjunctival scarring and concretions, and recurrent conjunctival and episcleral injection.
Results:
Four years after initial presentation, the patient developed hepatitis C, and 2 years later blisters on his scalp and hands. Direct immunofluorescence studies of biopsies taken from the palpebral conjunctiva of the right lower lid were negative for cicatricial pemphigoid. A twenty-four hour urine specimen analysis revealed elevated levels of uroporphyrins and polycarboxylated porphyrins, confirming the diagnosis of porphyria cutanea tarda. The patient was treated with repeated phlebotomies and oral hydroxychloroquine, which resulted in a significant decrease in the skin lesions, conjunctival injection, and concretions under the upper lids.
Conclusions:
Cicatricial conjunctivitis may be a manifestation of porphyria cutanea tarda.