Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

2.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
2.9K
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

115
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
115
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

73
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
73
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

2.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.0K
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

157
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
157
Clinical Trials01:16

Clinical Trials

6.7K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to van Rooij et al., "Clinical Context and Comparative Interpretation of Dermatologic Disease Burden in People With HIV in the Modern Antiretroviral Era".

Journal of the American Academy of Dermatology·2026
Same author

JAAD Game Changers: Early postoperative water exposure does not increase complications in cutaneous surgeries: a randomized, investigator-blinded, controlled trial.

Journal of the American Academy of Dermatology·2026
Same author

JAAD Game Changers: No evidence for an association between benzoyl peroxide use and increased blood benzene levels in the National Health and Nutrition Examination Survey.

Journal of the American Academy of Dermatology·2026
Same author

Formulary Coverage of Topical Rosacea Therapies in United States Commercial Insurance: A Cross-Sectional Review.

Journal of drugs in dermatology : JDD·2026
Same author

Update on Granulomatous Dermatoses: Clinical Features and Therapeutic Advances.

Journal of drugs in dermatology : JDD·2026
Same author

Understanding Patient Perspectives on Rosacea: A Cross-Sectional Analysis of the r/Rosacea Forum on Reddit.

Journal of drugs in dermatology : JDD·2026
Same journal

GLP-1 Receptor Agonists in Hidradenitis Suppurativa-Emerging Opportunities for Comorbidity Management?

JAMA dermatology·2026
Same journal

Topical Preparations for Moderate to Severe Rosacea Treatment: A Systematic Review and Network Meta-Analysis.

JAMA dermatology·2026
Same journal

GLP-1 Receptor Agonist Use and Clinical Outcomes in Patients With Hidradenitis Suppurativa.

JAMA dermatology·2026
Same journal

BRAF Inhibition in Congenital Nevi and Neural Melanosis.

JAMA dermatology·2026
Same journal

The Absent Original in Smartphone Photography.

JAMA dermatology·2026
Same journal

A Tribute to a Master Clinician: Richard Odom.

JAMA dermatology·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2025

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

7.2K

Rosacea Core Domain Set for Clinical Trials and Practice: A Consensus Statement.

McKenzie A Dirr1, Areeba Ahmed1, Daniel I Schlessinger1

  • 1Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

JAMA Dermatology
|April 24, 2024
PubMed
Summary
This summary is machine-generated.

Standardizing outcomes in rosacea clinical trials is crucial for data pooling. A new core outcome set (COS) was developed, including 8 key domains for consistent reporting in research and clinical practice.

More Related Videos

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

2.3K
Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
03:10

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid

Published on: November 1, 2024

2.5K

Related Experiment Videos

Last Updated: Jun 28, 2025

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

7.2K
Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

2.3K
Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
03:10

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid

Published on: November 1, 2024

2.5K

Area of Science:

  • Dermatology and clinical trial methodology.

Background:

  • Inconsistent outcome reporting in rosacea clinical trials hinders data aggregation and meta-analyses.
  • Standardization of outcomes is needed for reliable assessment in rosacea intervention studies.

Purpose of the Study:

  • To develop a globally relevant rosacea core outcome set (COS).
  • To establish a minimum list of outcomes for rosacea clinical trials and clinical practice.

Main Methods:

  • Systematic literature review of rosacea trials to identify discrete outcomes.
  • Delphi process involving 88 international panelists (physicians and patients) to rate outcomes.
  • Consensus meetings to finalize the core domain set based on participant ratings.

Main Results:

  • An initial list of 192 outcomes was refined to 50, then finalized into 8 core domains.
  • The 8 core domains include ocular and skin signs/symptoms, overall severity, patient satisfaction, quality of life, improvement degree, and adverse events.
  • Recommendations for clinical application were also established.

Conclusions:

  • The developed core domain set provides a standardized framework for rosacea research.
  • Adoption of this COS will enhance the comparability and meta-analytic potential of future rosacea trials.
  • The COS may also serve as a valuable tool in clinical practice for assessing rosacea outcomes.