Investigation on Huntington's disease. III. Biochemical observations, a possibly predictive test?

The possible biochemical basis underlying the aetiology and pathogenesis of Huntington's disease (H.D.) is discussed. The development of a predictive test for presymptomatic detection of the disorder, based on measurement of serum caeruloplasmin and serum dopamine beta-hydroxylase (DBH) is also described. Possible means of appraising the proposed test are suggested.