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Post surgical pain management with poly(ortho esters).
John Barr1, Kathryn W Woodburn, Steven Y Ng
1A.P. Pharma, 123 Saginaw Drive, Redwood City, CA 94063, USA. jbarr@appharma.com
Advanced Drug Delivery Reviews
|October 18, 2002
Summary
New Poly(ortho esters) (POE IV) polymers offer controlled drug release for sustained pain management. This injectable material modulates surface erosion, enabling long-acting anesthesia with agents like mepivacaine.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Poly(ortho esters) (POE) are bioerodible synthetic polymers with tunable properties.
- Advancements in POE, specifically POE IV, integrate latent acid for controlled surface erosion.
- Surface erosion is crucial for moderating drug release kinetics.
Purpose of the Study:
- To evaluate the potential of POE IV as a drug delivery vehicle for sustained post-surgical pain management.
- To investigate the incorporation of mepivacaine into injectable POE IV formulations.
- To assess the drug release profile and anesthetic duration in preclinical models.
Main Methods:
- Formulation of viscous, injectable POE IV polymers.
- Incorporation of the local anesthetic mepivacaine into the POE IV matrix.
- Evaluation of drug release and anesthetic properties in non-clinical settings.
Main Results:
- POE IV demonstrates predominantly surface erosion, enabling controlled drug release.
- The polymer system can moderate drug release over extended periods (days to months).
- Injectable POE IV formulations show potential for longer-acting anesthesia.
Conclusions:
- POE IV is a promising biomaterial for controlled drug delivery applications.
- The polymer's surface erosion properties are advantageous for sustained release formulations.
- POE IV holds potential for advanced post-surgical pain management strategies.