Is the partial Mantel test inadequate?
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Updated: Sep 28, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
Published on: May 10, 2021
Sergio Castellano1, Emilio Balletto
1Dipartimento di Biologia Animale e dell'Uomo, Torino, Italy. sergio.castellano@unito.it
Abstract:
A publication by Raufaste and Rousset (2001) questioned the effectiveness of the partial Mantel test, a nonparametric statistical test for association among three distance matrices. By repeated simulations, we calculated the cumulative density functions of the null-hypothesis probability of no correlation, within an explicit model of causal relationships. Results do not support the criticism: in conditions of moderate correlation between the independent matrices, the actual error rate is closely associated to the intended type-I error alpha.
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