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Hyaline-vascular type Castleman's disease involving both orbits
Keun-Sung Park1, You-Jin Choi, Kyu-Sang Song
1Department of Ophthalmology, College of Medicine, Chungnam National University, Taejon, South Korea. ksparkmd@cnu.ac.kr
Insights
Hyaline-vascular Castleman's disease (CD) presented as an isolated upper eyelid mass in an 18-year-old woman. Surgical excision was curative, highlighting CD as a rare cause of orbital tumors.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Castleman's disease (CD) is a rare lymphoproliferative disorder.
- Hyaline-vascular type is the most common subtype of CD.
- CD can present with diverse clinical manifestations.
Observation:
- An 18-year-old woman presented with bilateral upper eyelid swelling.
- Initial examination revealed an isolated orbital mass.
- The patient underwent surgical excision of the mass.
Findings:
- Histopathology confirmed hyaline-vascular type Castleman's disease.
- The patient remained asymptomatic one year post-surgery.
- No clinical or laboratory abnormalities were detected post-treatment.
Implications:
- Castleman's disease should be considered in the differential diagnosis of orbital masses.
- Early diagnosis and treatment, such as surgical excision, can lead to favorable outcomes.
- Orbital involvement of CD warrants ophthalmological attention.
Purpose:
To describe a patient with hyaline-vascular type Castleman's disease (CD) whose initial examination revealed only upper eyelid mass. Further, to review all aspects of CD.
Methods:
Case report. An 18-year-old woman initially presented with swelling of both upper eyelids. She underwent an anterior orbitotomy with surgical excision followed by close observation.
Results:
Histopathological examination of the upper eyelid mass confirmed the presence of hyaline-vascular type CD. One year after surgical treatment, the patient is still asymptomatic, with no pathologic clinical or laboratory findings.
Conclusions:
Castleman's disease is a rare but valid clinical entity. It should be considered in the differential diagnosis of asymptomatic orbital mass. Our understanding of CD has advanced recently. The treatment modalities for CD (e.g. surgical excision, radiation therapy and combination chemotherapy) are usually curative and optimizing. Castleman's disease involving the orbital area is now attracting ophthalmological interest.
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