Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Sentinel lymph node drainage in multicentric breast cancers.

Hong Jin Kim¹, Alexandra S Heerdt, Hiram S Cody

¹Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

The Breast Journal

|October 23, 2002

Summary

Sentinel lymph node biopsy is a crucial tool for breast cancer staging. This study suggests it may be accurate even in multicentric breast cancers, potentially reducing unnecessary surgeries.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Safety and Radiological Outcomes of Posterior-Based Minimally Invasive Scoliosis Surgery in Young Adult Idiopathic Scoliosis: A Comparative Study Based on Age.

Operative neurosurgery (Hagerstown, Md.)·2026

Same author

Sagittal Profiles and Their Reciprocal Changes Manifesting in Proximal Junctional Kyphosis Following Deformity Correction in Adolescent Idiopathic Scoliosis.

Global spine journal·2026

Same author

Influence of acetabular dysplasia and associated radiological indicators on hip joint motion in asymptomatic individuals.

Journal of hip preservation surgery·2026

Same author

Discordance in spinopelvic alignment between weight-bearing and supine positions on three-dimensional computed tomography.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026

Same author

Sentinel Lymph Node Biopsy for Patients With cN1 HR+/HER2- Breast Cancer and Palpable Adenopathy: A Nonrandomized Clinical Trial.

JAMA surgery·2026

Same author

Safety of Pre-Operative Radiotherapy Combined With Intraoperative Radiotherapy for Retroperitoneal Sarcoma.

Journal of surgical oncology·2026

Area of Science:

Oncology
Surgical Oncology
Breast Cancer Research

Background:

Axillary lymph node status is critical for breast cancer prognosis and treatment decisions.
Sentinel lymph node (SLN) biopsy aims to spare node-negative patients morbidity associated with axillary lymph node dissection (ALND).
Standardization of SLN biopsy techniques and understanding breast lymphatic drainage remain challenges, with multicentricity often being a contraindication.

Observation:

This report details five cases of patients with multicentric breast cancers.
Each patient had tumors in two distinct quadrants.
Dual-site injection with technetium-labeled sulfur colloid and isosulfan blue dye successfully identified sentinel nodes in the axilla.

Findings:

The study successfully identified sentinel lymph nodes in all five cases of multicentric breast cancer.

Related Experiment Videos

Nodes were identified as both 'hot' (radioactive) and 'blue' (dye-stained).

These findings suggest that lymphatic drainage from different breast quadrants converges, even with multiple primary tumors.

Implications:

The results indicate that SLN biopsy may be accurate for staging multicentric breast cancers.
This could potentially allow more patients with multicentric disease to avoid extensive axillary lymph node dissection.
Further research is necessary to confirm the reliability and accuracy of SLN biopsy in this patient population.