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Updated: Aug 19, 2026

One-step Protocol for Evaluation of the Mode of Radiation-induced Clonogenic Cell Death by Fluorescence Microscopy
Published on: October 23, 2017
[Relationship between apoptotic activity and radiosensitivity in solid tumors: does apoptosis always bring good
1Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University.
Abstract:
Apoptosis has recently been considered to be a predictor of tumor response or outcome following chemotherapy or radiotherapy. Although apoptosis clearly occurs in the very early stages following such treatments, it is unclear whether its frequency correlates with the likelihood of tumor cure following radiotherapy, especially in solid tumors, where the major mode of cell death is necrosis. This review discuses the relationship between apoptotic activity and radiosensitivity or tumor response from various points of view, including experimental systems and clinical conditions.
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