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Updated: Jul 29, 2026
A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
Published on: November 9, 2017
[Natural autoantibodies against MP65 and ACBP14/18 and ontogenic formation of rat nervous system]
S V Vakhrushina1, E P Anan'eva, A S Shinkarev
1Medico-Ecological Foundation Chernobyl-Test, Moscow.
Abstract:
It was demonstrated that passive immunization of pregnant female rats against MP65 and ACBP14/18 proteins leads to stable changes in offspring behavior (deviations in acquisition of active avoidance in a shuttle-box and changes in the open-field behavior). Immunomorphological data about localization of MP65 and ACBP14/18 proteins in brain slices of adult rats and rat embryos are presented. The obtained results are discussed in terms of the influence of maternal humoral immunity on the formation of fetal nervous system during intrauterine development.
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