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What's the matter with HIV-directed killer T cells?
1Statistical Center for HIV and AIDS Research and Prevention, MW-500, Fred Hutchinson Cancer Research Center, 1124 Columbia St. Seattle, WA, 98104-2092, U.S.A. wick@scharp.org
Journal of Theoretical Biology
|October 24, 2002
Abstract:
That HIV-specific cytotoxic T-lymphocytes (CTLs) might be defective in some way has stimulated much controversy and research. We use mathematical models to explore the predictions of two competing CTL-defect theories: "defective memory" and "defective activation". We discuss whether these models are consistent with adoptive-transfer experiments in HIV-infected patients and vaccine trials in simian immunodeficiency virus (SIV)-infected monkeys. Finally, we describe experimental tests that could decide among these two theories and a competitor: CTL exhaustion.