Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Saliva cyclic GMP increases during anaesthesia.

T Engelhardt1, H F Galley, F M MacLennan

  • 1Academic Unit of Anaesthesia and Intensive Care, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK.

British Journal of Anaesthesia
|October 24, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SARS-CoV-2 airway reactivity in children: more of the same?

Anaesthesia·2022
Same author

[Definition of the quality of hand surgery].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2021
Same author

[Challenges to endoprosthetic reconstruction after tumor resection around the knee : Management of intra- and postoperative complications].

Der Orthopade·2020
Same author

Perioperative medicine and UK plc.

British journal of anaesthesia·2018
Same author

Incidence of severe critical events in paediatric anaesthesia in the United Kingdom: secondary analysis of the anaesthesia practice in children observational trial (APRICOT study).

Anaesthesia·2018
Same author

Airway management in paediatric anaesthesia in Europe-insights from APRICOT (Anaesthesia Practice In Children Observational Trial): a prospective multicentre observational study in 261 hospitals in Europe.

British journal of anaesthesia·2018
Same journal

Audit of procedural sedation complications using a novel digital application.

British journal of anaesthesia·2026
Same journal

Social deprivation and morbidity and mortality after surgery. Comment on Br J Anaesth 2025; 135: 1193-1202.

British journal of anaesthesia·2026
Same journal

Single-dose intraoperative methadone and QTc interval: a prospective observational cohort investigation.

British journal of anaesthesia·2026
Same journal

Postoperative outcomes in older patients with postoperative delirium in the UK: timing of postoperative delirium screening in the SNAP-3 study. Comment on Br J Anaesth 2026; 136: 1578-87.

British journal of anaesthesia·2026
Same journal

Population pharmacokinetic-pharmacodynamic analysis and dose optimisation of ciprofol in paediatric anaesthesia.

British journal of anaesthesia·2026
Same journal

Global environmental and geo-economic impact of conservative versus liberal oxygen strategies in mechanically ventilated critically ill adults: an ecological country-level analysis.

British journal of anaesthesia·2026
See all related articles

Salivary cyclic GMP (cGMP) levels significantly increased during general anesthesia in patients, unlike in healthy volunteers. This finding may offer a new way to monitor anesthesia depth in real-time.

Area of Science:

  • Anesthesiology
  • Biochemistry
  • Physiology

Background:

  • Cyclic GMP (cGMP) plays a role in modulating general anesthesia effects.
  • Previous studies have not reported on human changes in cGMP during anesthesia.

Purpose of the Study:

  • To investigate real-time changes in salivary cGMP levels during general anesthesia in humans.
  • To explore the potential of salivary cGMP as a biomarker for anesthesia depth.

Main Methods:

  • A pilot study measured salivary cGMP in 6 healthy volunteers and 8 patients undergoing general anesthesia.
  • cGMP was quantified using an enzyme immunoassay on samples collected with a commercial device.
  • Results were normalized to protein concentration.

Main Results:

Related Experiment Videos

  • Healthy volunteers showed no significant day-to-day or time-dependent variations in salivary cGMP.
  • Patients undergoing general anesthesia exhibited a significant intraoperative increase in salivary cGMP.
  • Salivary cGMP levels returned to preoperative baseline after the surgical procedure (P=0.03).

Conclusions:

  • This study provides the first demonstration of in vivo changes in human salivary cGMP during general anesthesia.
  • Salivary cGMP monitoring may represent a novel, non-invasive method for assessing anesthesia depth in clinical practice.