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Clinical acceptance of two multipurpose solutions: MPS containing HPMC versus citrate-based MPS without rubbing
Michel Guillon1, Cecile Maissa
1Vision Research Consultants, Optometric Technology Group Ltd., London, UK. circ@otg.co.uk
Purpose:
This study evaluated the clinical performance of contact lens wear, primarily comfort and dryness during the daytime and at the end of the day, associated with the use of a multipurpose solution containing hydroxypropyl methylcellulose (HPMC), COMPLETE ComfortPLUS (Allergan, Irvine, CA) compared to a citrate-based multi-purpose disinfecting solution used without manual rubbing, NO RUB OPTI-FREE EXPRESS (Alcon, Ft. Worth, TX).
Methods:
This randomized, investigator-masked, cross-over study was conducted with 64 subjects who underwent adaptation and were planned-replacement lens wearers. Each solution was used by the subject for 1 month, with a 1-week wash-out period during which the subject's own solutions were used. When new solutions were issued, new contact lenses also were dispensed.
Results:
The level of comfort, the primary endpoint of the study, in the evening (on a 50-point scale) was rated better with OPTI-FREE EXPRESS at the end of the 1-month period of wear (mean 39 vs. 37, P=0.03). Dryness, the most frequently reported symptom, occurred at a similar level of rating with both care systems (P >0.05). Few other clinically significant differences between the regimens were noted.
Conclusions:
The overall clinical performance of the citrate-based solution used without manual rubbing was similar to that of the solution containing HPMC. The subjective results of comfort-level and dryness with the two regimens demonstrated that the inclusion of HPMC did not provide unique performance advantages.
Insights
This study found that a citrate-based multipurpose solution without rubbing performed similarly to a hydroxypropyl methylcellulose (HPMC) solution for contact lens comfort and dryness. HPMC did not offer unique advantages in this clinical comparison.
Area of Science:
- Ophthalmology
- Biomaterials Science
Background:
- Contact lens care solutions are crucial for maintaining lens hygiene and wearer comfort.
- Multipurpose solutions (MPS) offer convenience, with some formulations incorporating specific ingredients like hydroxypropyl methylcellulose (HPMC) to enhance comfort.
Purpose of the Study:
- To compare the clinical performance, specifically comfort and dryness, of a HPMC-containing MPS (COMPLETE ComfortPLUS) against a citrate-based MPS used without rubbing (NO RUB OPTI-FREE EXPRESS).
Main Methods:
- A randomized, investigator-masked, cross-over study involving 64 planned-replacement contact lens wearers.
- Participants used each MPS for one month, separated by a one-week washout period.
- New contact lenses were dispensed with each new solution trial.
Main Results:
- Comfort ratings in the evening were slightly higher for NO RUB OPTI-FREE EXPRESS (mean 39) compared to COMPLETE ComfortPLUS (mean 37), with statistical significance (P=0.03).
- Dryness, the most common complaint, showed no significant difference between the two MPS.
- No other significant clinical differences were observed between the care systems.
Conclusions:
- The citrate-based MPS used without rubbing demonstrated comparable clinical performance to the HPMC-containing MPS.
- The inclusion of HPMC in the tested MPS did not yield superior subjective outcomes regarding comfort or dryness.