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The biologic response to particles from a lumbar disc prosthesis
Robert J Moore1, Robert D Fraser, Barrie Vernon-Roberts
1Adelaide Centre for Spinal Research, Institute of Medical and Veterinary Science, Department of Pathology, Adelaide University, Australia. rob.moore@imvs.sa.gov.au
Spine
|October 24, 2002
Summary
Polyolefin rubber particles in lumbar disc prostheses showed a normal foreign body reaction in animal models. These particles did not migrate or cause toxic effects, indicating localized biocompatibility.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Toxicology
Background:
- Intervertebral disc prostheses offer an alternative to spinal fusion for degenerative disc disease.
- Verification of biocompatibility for all implant components is crucial for patient safety.
Purpose of the Study:
- To evaluate the tissue response and biocompatibility of polyolefin rubber particles intended for use in lumbar disc prostheses.
Main Methods:
- Polyolefin rubber particles were generated in vitro.
- Particles were implanted into subcutaneous air pouches in rats and onto the dura mater and nerve roots in sheep.
- Histological examination assessed inflammation and healing responses.
Main Results:
- Polyolefin rubber particles elicited a localized foreign body reaction, comparable to ultrahigh molecular weight polyethylene particles.
- No evidence of particle migration from implantation sites was observed.
- No local or systemic toxic effects were detected.
Conclusions:
- Polyolefin rubber particles demonstrate biocompatibility, inducing only a localized tissue response.
- The observed reaction is consistent with a normal foreign body response to large, non-toxic particles.