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Published on: June 6, 2017
Roles for cytoplasmic polyadenylation in cell cycle regulation
Rebecca L Read1, Chris J Norbury
1Cancer Research UK Molecular Oncology Laboratory, University of Oxford Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
Journal of Cellular Biochemistry
|October 25, 2002
Summary
Cytoplasmic polyadenylation, regulated by the conserved cid1 gene family, activates mRNA translation for cell cycle control. This mechanism is crucial for cell cycle regulation, especially after DNA synthesis inhibition.
Area of Science:
- Molecular Biology
- Gene Expression Regulation
- Cell Cycle Control
Background:
- Nuclear polyadenylation enhances mRNA translation and stability.
- Cytoplasmic polyadenylation controls gene expression, particularly for oocyte cell cycle events.
- This cytoplasmic mechanism is increasingly recognized as widespread in eukaryotes.
Purpose of the Study:
- To discuss the roles of the cid1 gene family in cell cycle regulation.
- To highlight the function of specific cid1 family members as cytoplasmic poly(A) polymerases.
- To emphasize the importance of cytoplasmic polyadenylation in response to DNA synthesis inhibition.
Main Methods:
- Literature review and discussion of existing biochemical studies.
- Analysis of conserved nucleotidyl transferase family (cid1 gene family).
- Focus on biochemical evidence for cytoplasmic poly(A) polymerase activity.
Main Results:
- The cid1 gene family, conserved across eukaryotes, plays a role in cell cycle regulation.
- A subset of these nucleotidyl transferases function as cytoplasmic poly(A) polymerases.
- These enzymes target specific mRNAs for translational activation.
Conclusions:
- Cytoplasmic polyadenylation by cid1 family members is a key mechanism for translational control.
- This process is vital for cell cycle progression, particularly after DNA damage.
- The cid1 gene family represents a conserved pathway for regulating gene expression post-transcriptionally.
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