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Bioparticle Microarrays for Chemotactic and Molecular Analysis of Human Neutrophil Swarming in vitro
Published on: February 16, 2020
[Annexin I-induced aggregation of human neutrophil gelatinase granules]
1Ogarev Mordovian State University, ul. Bolshevistskaya 68, Saransk, 430000 Russia.
Abstract:
The ability of neutrophil cytosol to induce the aggregation of gelatinase granules of human neutrophils was studied. The cytosol was found to induce the Ca(2+)-dependent aggregation of granules. The stimulatory effect of cytosol was considerably reduced in the presence of the monoclonal antibody recognizing annexin I. Annexin I is a mediator of Ca(2+)-dependent aggregation of gelatinase granules and probably participate in granule secretion.
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