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Updated: Sep 28, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Pachyclavulariaenones D-G, new diterpenoids from the soft coral Pachyclavularia violacea
Guey-Horng Wang1, Jyh-Horng Sheu, Chang-Yih Duh
1Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan, Republic of China.
Abstract:
Four new diterpenoids, pachyclavulariaenones D-G (1-4), have been isolated from the soft coral Pachyclavularia violacea. The structures and relative stereochemistry of metabolites 1-4 were established on the basis of extensive NMR studies and chemical methods. The structure, including the relative configuration of pachyclavulariaenone F (3), was further confirmed by a single-crystal X-ray analysis. Pachyclavulariaenone G (4) has been shown to exhibit significant cytotoxicity toward P-388 and HT-29 cancer cells.
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