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Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with
Tracy Murray-Stewart1, Yanlin Wang, Wendy Devereux
1Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Bunting Blaustein Building, Room 551, 1650 Orleans Street, Baltimore, MD 21231, USA.
The Biochemical Journal
|October 26, 2002
Abstract:
The recently cloned and characterized human polyamine oxidase (PAOh1) potentially represents a new class of catabolic enzymes in the mammalian polyamine metabolic pathway capable of the efficient oxidation of polyamines. Here the discovery of three additional human PAO splice variants is reported, and the data support the fact that the human PAO gene codes for at least four isoenzymes, each of which exhibit distinctive biochemical characteristics, suggesting the existence of additional levels of complexity in polyamine catabolism.