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Updated: Jun 25, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Topical tacrolimus for repigmentation of vitiligo.

Pearl E Grimes1, Teresa Soriano, Marlene T Dytoc

  • 1Vitiligo and Pigmentation Institute of Southern California, Los Angeles, CA, USA. pegrimesmd@earthlink.net

Journal of the American Academy of Dermatology
|October 26, 2002
PubMed
Summary
This summary is machine-generated.

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Tacrolimus ointment shows promise for treating generalized vitiligo, with 5 out of 6 patients experiencing significant skin repigmentation. This study suggests it may be an effective and safe therapeutic option for vitiligo patients.

Area of Science:

  • Dermatology
  • Immunology

Background:

  • Vitiligo is a chronic autoimmune condition characterized by depigmentation.
  • Current treatments for generalized vitiligo have variable efficacy and potential side effects.

Purpose of the Study:

  • To evaluate the efficacy and safety of topical tacrolimus ointment in patients with generalized vitiligo.

Main Methods:

  • A series of 6 patients with generalized vitiligo were treated with tacrolimus ointment.
  • The study was noncontrolled and nonblinded.

Main Results:

  • Five out of six patients achieved moderate to excellent repigmentation.
  • Tacrolimus ointment was generally well-tolerated by the patients.

Conclusions:

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  • Topical tacrolimus ointment may be an effective and safe treatment for generalized vitiligo.
  • Further controlled studies are warranted to confirm these findings.