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Carbon paste electrode based on surface activation for trace adriamycin determination by a preconcentration and
Shenghui Zhang1, Kangbing Wu, Shengshui Hu
1Department of Chemistry, Wuhan University, PR China.
Summary
This study presents a sensitive voltammetric method for determining adriamycin (ADM) using a carbon paste electrode modified with cetyltrimethylammonium bromide (CTAB). The optimized method achieves a low detection limit for ADM in urine samples from chemotherapy patients.
Area of Science:
- Electrochemistry
- Analytical Chemistry
- Pharmacology
Background:
- Adriamycin (ADM) is a crucial chemotherapeutic agent requiring precise quantification.
- Existing analytical methods for ADM may lack sensitivity or require complex sample preparation.
- Development of sensitive and efficient methods for ADM determination is essential for therapeutic drug monitoring.
Purpose of the Study:
- To develop and optimize a sensitive voltammetric method for adriamycin (ADM) determination.
- To investigate the electrochemical behavior of ADM at a carbon paste electrode (CPE) modified with cetyltrimethylammonium bromide (CTAB).
- To validate the method for quantifying ADM in biological samples, specifically patient urine.
Main Methods:
- Voltammetric analysis using a carbon paste electrode (CPE).
- Electrode surface modification with cetyltrimethylammonium bromide (CTAB) to enhance ADM adsorption.
- Optimization of experimental parameters including pH, surfactant concentration, and scan rate.
- Linear sweep voltammetry for ADM quantification.
Main Results:
- ADM exhibits enhanced reduction current at the CTAB-modified CPE due to strong adsorption.
- The method demonstrates a linear relationship between peak current and ADM concentration from 2.5 x 10(-8) to 5 x 10(-6) mol/L.
- A low detection limit of 4 x 10(-10) mol/L was achieved with a 3-minute accumulation time.
- The method showed good precision with a coefficient of variation of 3.0% at 4 x 10(-6) mol/L ADM.
- Successful determination of ADM in urine samples from patients undergoing chemotherapy.
Conclusions:
- The developed voltammetric method using a CTAB-modified CPE is highly sensitive and effective for ADM determination.
- This technique offers a reliable approach for monitoring ADM levels in clinical settings.
- The method's sensitivity and applicability to real urine samples highlight its potential for therapeutic drug monitoring in cancer chemotherapy.
