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Regulation of lymphoid homeostasis by interleukin-15
James P Lodolce1, Patrick R Burkett, Rima M Koka
1Department of Medicine, Ben May Institute for Cancer Research, University of Chicago, 5841 S Maryland Ave MC 6084, Chicago, IL 60637, USA.
Cytokine & Growth Factor Reviews
|October 29, 2002
Abstract:
Interleukin (IL)-15 is a member of the common gamma chain family of cytokines, and is closely related to IL-2. While these two cytokines share several important biological functions in vitro, recent mouse models have demonstrated unique roles for these two cytokines in supporting lymphoid homeostasis in vivo. IL-15 has been shown to regulate the homeostasis of both innate and adaptive immune cells, and this review will discuss several ways in which this pleiotropic cytokine may support lymphoid homeostasis.