Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histopathologic changes in the vestibule after cochlear implantation.

Hui-Chi Tien1, Fred H Linthicum

  • 1House Ear Institute, Los Angeles, CA 90057, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|October 29, 2002
PubMed
Summary

Cochlear implantation can cause significant vestibular end-organ damage, including fibrosis and new bone formation. Placing the electrode array in the scala tympani may minimize this damage, even if symptoms are not apparent.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Matrix Metalloproteinase-8 Polymorphisms on Nasopharyngeal Carcinoma Risk.

Anticancer research·2024
Same author

Association of <i>Matrix Metalloproteinase-9</i> Genotypes With Nasopharyngeal Carcinoma Risk.

In vivo (Athens, Greece)·2024
Same author

Efficacy of Adjuvant Sublingual Immunotherapy After Septomeatoplasty.

The Laryngoscope·2024
Same author

Endoscopic Versus Microscopic Type I Tympanoplasty: An Updated Systematic Review and Meta-analysis.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2023
Same author

Corrigendum: Characterizing Adult Cochlear Supporting Cell Transcriptional Diversity Using Single-Cell RNA-Seq: Validation in the Adult Mouse and Translational Implications for the Adult Human Cochlea.

Frontiers in molecular neuroscience·2021
Same author

Neurofibromatosis type 2 initially presenting as a preauricular mass: a case report.

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale·2020

Area of Science:

  • Otolaryngology
  • Neuroscience
  • Histopathology

Background:

  • Cochlear implantation is a common treatment for severe to profound hearing loss.
  • Potential side effects, such as vestibular dysfunction, require thorough investigation.

Purpose of the Study:

  • To histopathologically assess vestibular end-organ changes following cochlear implantation.
  • To correlate these changes with clinical outcomes and implantation techniques.

Main Methods:

  • Light microscopy analysis of 11 pairs of human temporal bones from unilateral cochlear implant recipients.
  • Comparison of vestibular damage between implanted and non-implanted ears to distinguish surgical effects from disease processes.

Main Results:

Related Experiment Videos

  • Significant histopathologic vestibular damage observed in 54.5% of implanted ears.
  • Common findings included fibrosis, saccule membrane distortion, new bone formation, and neuromas.
  • Scala vestibuli involvement, linked to basal turn cochlear damage, strongly correlated with vestibular damage (75%).

    • Conclusions:

    • Vestibular end-organ damage can occur post-cochlear implantation, potentially asymptomatically.
    • Minimizing vestibular damage is achievable by maintaining the electrode array within the scala tympani.