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Related Experiment Videos

Thrombin potential and thrombin generation after exhaustive exercise.

T Hilberg1, D Prasa, J Stürzebecher

  • 1Department of Sports Medicine, Friedrich-Schiller-University Jena, Germany. t.hilberg@ghz.de

International Journal of Sports Medicine
|October 29, 2002
PubMed
Summary

Exhaustive exercise activates blood coagulation, but the potential for thrombin generation remains unchanged in healthy males. This suggests alpha 2-macroglobulin counterbalances any increase, regardless of exercise type.

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Area of Science:

  • Sports Medicine
  • Hematology
  • Physiology

Background:

  • Exhaustive exercise is known to activate blood coagulation.
  • The clinical significance of this activation, particularly regarding thrombin generation potential, remains unclear.

Purpose of the Study:

  • To investigate the existence of a hypercoagulant state after exhaustive exercise.
  • To determine if exhaustive exercise impacts intrinsic and extrinsic thrombin generation potential.

Main Methods:

  • Thirteen healthy males performed exhaustive treadmill and cycle ergometer tests.
  • Blood samples were analyzed for total thrombin potential (TTP), endogenous thrombin potential (ETP), aPTT, PT, F1+2, and TAT at various time points.

Main Results:

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  • Intrinsic TTP significantly increased post-exercise, while ETP remained unchanged.
  • Activated partial thromboplastin time (aPTT) shortened, and F1+2 concentrations increased, indicating coagulation activation.
  • No significant differences were observed between treadmill and cycle exercise.

    • Conclusions:

    • Coagulation is activated post-exhaustive exercise, evidenced by increased F1+2 and shortened aPTT.
    • The potential for thrombin generation (ETP) is not significantly altered, suggesting it is counterbalanced by alpha 2-macroglobulin.
    • Thrombin generation potential appears independent of the type of exhaustive exercise performed in healthy young males.