Correlation between oxidized low-density lipoprotein and other factors in patients on peritoneal dialysis

Oxidized low-density lipoprotein (Ox-LDL) has been related with progression of atherosclerosis. Some studies reported increased Ox-LDL levels in hemodialysis (HD) patients. The levels of Ox-LDL in peritoneal dialysis (PD) patients have not yet been clarified. We measured Ox-LDL in PD patients and investigated the related factors. We measured plasma Ox-LDL, total cholesterol (TC), triglycerides (TG), and LDL-cholesterol (LDL-c) levels in 18 PD patients (mean age: 55.5 +/- 9.8 years; mean duration of dialysis: 2.7 +/- 1.4 years) and in 24 HD patients as controls. We compared Ox-LDL levels in patients with diabetes mellitus (DM) and ischemic heart disease (IHD). And we looked at the correlation between Ox-LDL levels and adequacy of PD. Levels of Ox-LDL were significantly higher in the PD patients (2.24 +/- 1.14 ng/microgram LDL protein) than in the HD patients (1.43 +/- 0.90 ng/microgram LDL protein), and other lipids were higher in the PD patients. The Ox-LDL did not correlate with other lipids. The Ox-LDL levels of the PD patients with DM or IHD were higher than those of non DM or non IHD patients. The adequacy of PD did not correlate with Ox-LDL. Patients on PD, especially those with DM or IHD, showed elevated Ox-LDL levels. Special attention should be paid to the level of Ox-LDL and atherosclerosis in PD patients.