Related Experiment Video
Updated: Sep 28, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
Published on: July 8, 2025
[Carbamazepine and aggressive behavior: a review]
Abstract:
Carbamazepine which has been used as an anticonvulsivant for many years, has more recently been advocated for the control of aggressive behavior in epileptic and non epileptic populations. Carbamazepine is the drug of choice for patients whose aggressive outbursts are related to epilepsy. It appears that carbamazepine may also be affective in aggressive individuals with varying diagnoses (especially schizophrenic patients) but additional double-blind studies are needed. Patients experienced good control of aggressive behavior on carbamazepine in doses of 600 to 1,200 mg per day but the relationship of carbamazepine responsiveness to carbamazepine blood levels and concurrent medication (neuroleptic treatment) requires further studies. No significant problem has been encountered in the majority of patients receiving carbamazepine. However, it can rarely cause bone marrow suppression and hepatotoxicity so that blood counts and liver functions require monitoring.
Related Concept Videos
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...
Mania and Antimanic Drugs: Overview
Aggression
Antiepileptic Drugs: Glutamate Antagonists
