Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Neuroleptic-induced movement disorders: historical perspectives].

M A Wolf1, R Yassa, P M Llorca

  • 1Centre Hospitalier Douglas, Centre de Psychiatrie Communautaire, 6875, boulevard LaSalle, Verdun, Québec, Canada, H4H 1R3.

L'Encephale
|November 1, 1993
PubMed
Summary

Neuroleptic-induced parkinsonism and tardive dyskinesia are neurological side effects of antipsychotic medications. Research has evolved, identifying risk factors like age and gender, but these conditions remain a therapeutic challenge.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association Between Metabolic Syndrome, Obesity, and Cognitive Performances in Individuals With Bipolar Disorders: Cross-Sectional and Longitudinal Analyses in the FACE-BD Cohort.

Acta psychiatrica Scandinavica·2025
Same author

Substance use disorders in outpatients with bipolar disorder and pain complaints.

Journal of affective disorders·2025
Same author

Revolutionizing medical education: Surgery takes the lead in virtual reality research.

Surgery open science·2025
Same author

Relationships between cognition, functioning, and quality of life of euthymic patients with bipolar disorder: Structural equation modeling with the FACE-BD cohort.

European psychiatry : the journal of the Association of European Psychiatrists·2024
Same author

Self-reported suicidal ideation among individuals with first episode psychosis and healthy controls: Findings from the international multicentre EU-GEI study.

Schizophrenia research·2024
Same author

The contribution of cannabis use to the increased psychosis risk among minority ethnic groups in Europe.

Psychological medicine·2024

Area of Science:

  • Neurology
  • Psychopharmacology

Context:

  • The discovery of neuroleptics in the mid-20th century led to the identification of neurological side effects, specifically extrapyramidal symptoms.
  • Early descriptions of neuroleptic-induced parkinsonism date back to the 1950s, with ongoing debate about its nature as a side effect or therapeutic action.

Purpose:

  • To trace the historical emergence and characterization of neuroleptic-induced parkinsonism and tardive dyskinesia.
  • To review the evolution of terminology and understanding of these neurological side effects.
  • To summarize early epidemiological findings and evolving risk factors for tardive dyskinesia.

Summary:

  • Neuroleptic-induced parkinsonism was first described in the 1950s, coinciding with the introduction of neuroleptic drugs.
  • Tardive dyskinesia, characterized by persistent involuntary movements, was reported in the late 1950s and formally termed in 1964.

Related Experiment Videos

  • Early epidemiological studies revealed wide prevalence rates, with later research highlighting older age and female gender as key risk factors.

    • Impact:

    • Understanding the historical context of these side effects is crucial for current clinical practice and research.
    • The persistent challenge of managing tardive dyskinesia underscores the need for safer antipsychotic alternatives.
    • Variations in clinical presentation and interest across regions may reflect differences in prescribing practices and medicolegal environments.