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Updated: Jul 16, 2026

Detection of Toxin Translocation into the Host Cytosol by Surface Plasmon Resonance
Published on: January 3, 2012
Technetium-99m labeling of tityustoxin and venom from the scorpion Tityus serrulatus
E A Nunan1, V N Cardoso, T Moraes-Santos
1Faculdade de Farmácia da Universidade Federal de Minas Gerais, Av Olegário Maciel, 2360, 30180-112, Belo Horizonte, MG, Brazil.
Abstract:
The tityustoxin, the most toxic fraction from scorpion Tityus serrulatus venom, has been used as a tool in several neurochemical and neuropharmacological studies. Biological activities of labeled and unlabeled tityustoxin and venom were compared. The samples were labeled in the presence of stannous chloride and sodium borohydride with a yield of 60-70% for the venom and 75-85% for tityustoxin and then chromatographed in Sephadex G-10. Biological activities of tityustoxin and venom were preserved after labeling.
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